师资队伍

叶娟

专业代码:105600

专业名称:中药学

学术/专业型:专业型

职务

  • 硕士生导师

—— 个人简介 ——

个人简介:

叶娟,副研究员,硕士生导师。主持及参与国家/部省级等课题20余项;发表学术论文40余篇;作为主要完成人获南京中医药科学技术奖二等奖1项;参与发表论著1部;授权专利4项。现任江苏省药理学会中药药理专委会委员,江苏省合成生物标准化技术委员会委员。主要从事中药物质基础和作用机制研究,围绕代谢性疾病和中西医结合抗肿瘤方向,从中药复方或动物药中筛选天然有效的分子展开药理学和作用机制研究

近五年主持在研课题:

国家自然科学基金青年项目,82104508,王氏保赤丸通过B.pseudolongum PV8-2代谢产物拮抗ALD脂质沉积的作用机制研究,2022/01-2024/1230万元,主持,在研

授权专利:

[1]曹鹏,杨洋,方圆,蔡雪婷,赵冰,陈姣,叶娟.刺芒柄花素在制备预防和治疗周围神经病变药物中的应用,申请号:201911146576,申请日:2019.11.21 CN110742882A (CN110742882B) CN201911146576.8

[2]薛斌,叶娟,曹鹏,吴菁. 坎格列净在制备治疗结节性硬化症介导的疾病的药物中的用途.申请号:202110152014.5,申请日:2021.02.03 CN112807304B CN202110152014.5

[3]周云中,曹鹏,薛红卫,叶娟,王兆龙,徐佳佳,吴迪. 王氏保赤丸在制备预防和/或治疗酒精性肝损伤的药物中的应用,申请号:20211016829492021.02.05 CN112807375B CN202110168294.9

[4]杨洋,叶娟,曹鹏,任凌丽,赵冰,谭琴,陈钟,陈炜炜,陈艺芳.一种中药组合物在制备防治消化道肿瘤药物中的应用,CN113925952B CN202111412401.4

 

联系方式:juanye@njucm.edu.cn


擅长: 中药药效物质基础与机理研究(围绕糖尿病、脂肪肝、化疗神经病变等方向)

—— 发表文章 ——

近五年发表文章:

1. Song YeBin Chen Xinyu Liu Zhengwei Zhang Wenjing Zhao Haoran Wang Lingli Ren Bing Zhao Qian Zhou Xi Chen Yang Yang*Peng Cao* Juan Ye*(2023).Wangshi Baochi Pills alleviate alcoholic liver disease by regulating the gut microbiota composition in a mouse model.Pharmacological Research-Modern Chinese Medicine6(2023):100208.

2. Zhang Z# Juan Ye# X. Liu W. Zhao B. Zhao X. Gao H. Lan Y. Wu Y. Yang and P. Cao (2023). Huangqi Guizhi Wuwu decoction alleviates oxaliplatin-induced peripheral neuropathy via the gut-peripheral nerve axis. Chin Med 18(1): 114.

3. Juan Ye# Yaling Qi# Jiao Chen# Shihu Zhang# Boyuan Liu Xianwen Yuan Qi Cheng Yang Yang Furong Zhang Hongliang Gao Haoran Wang Jing Wu Feng Zhu* Chaojun Li* Peng Cao* Bin Xue*(2022)Alleviation of hepatic steatosis by 4-azidophlorizin via the degradation of geranylgeranyl diphosphate synthase by the ubiquitin-proteasome pathway in vivo and in vitro. Advanced biology.Adv Biol 7(9): e2200150.

4. Ye J Ke L Xu Y Yang Y Zhou Q Gao W Cai X Wei Q Cao M Cao P*(2022)Salivary antimicrobial factors influence microbial composition of tongue coating in patients with coronary heart disease having Phlegm-stasis Syndrome. World Journal of Traditional Chinese Medicine.8:1123-130.

5. Ren L Zhang Z Zhao W Zhao B Chen X Wang Y Chen Z Ye J* Yang Y* Cao P*(2022) Qingchang Wenzhong Decoction Prevents the Occurrence of Intestinal Tumors by Regulating Intestinal Microbiota and Gasdermin E. Frontiers in physiology 13:917323.

6. Chen Y Xu E Sang M Wang Z Zhang Y Ye J Zhou Q Zhao C Hu C Lu W Cao P(2022)Makatoxin-3 a thermostable Nav1.7 agonist from Buthus martensii Karsch (BmK) scorpion elicits non-narcotic analgesia in inflammatory pain models. Journal of ethnopharmacology 288:114998.

7. Cao L Xu E Zheng R Zhangchen Z Zhong R Huang F Ye J Sun H Fan Y Xie S Chen Y Xu Y Cao J Cao W Liu C(2022) Traditional Chinese medicine Lingguizhugan decoction ameliorate HFD-induced hepatic-lipid deposition in mice by inhibiting STING-mediated inflammation in macrophages. Chinese medicine 17(1):7.

8. Hua D Yang J Meng Q Ling Y Wei Q Wang Z Wei Q Chen J Ye J Han X Su K Kong W Xu C Cao P Hu C(2021) Soufeng sanjie formula alleviates collagen-induced arthritis in mice by inhibiting Th17 cell differentiation. Chinese medicine 16(1):39.

9. Ren L# Ye J# Zhao B Sun J Cao P* and Yang Y* (2021) The Role of Intestinal Microbiota in Colorectal Cancer. Front. Pharmacol. 12:674807.

10. Ye J Cai X Wang D Zhang F Wang Z Cao M Pang Z Yang J Yan H Li J Cao P Hu C (2020) Shi Xiao San ameliorates the development of adenomyosis in an ICR mouse model. Experimental and therapeutic medicine 20:2845-2855

11. Fang Y# Ye J# Zhao B Sun J Gu N Chen X Ren L Chen J Cai X Zhang W Yang Y Cao P (2020) Formononetin ameliorates oxaliplatin-induced peripheral neuropathy via the KEAP1-NRF2-GSTP1 axis. Redox biology 36:101677

12. Yuan X Sun Y Cheng Q Hu K Ye J Zhao Y Wu J Shao X Fang L Ding Y Sun X Shi X Xue B (2020) Proteomic analysis to identify differentially expressed proteins between subjects with metabolic healthy obesity and non-alcoholic fatty liver disease. Journal of proteomics 221:103683

13. Gui Z# Zhu J# Ye S Ye J Chen J Ling Y Cai X Cao P He Z Hu C (2020) Prolonged melittin release from polyelectrolyte-based nanocomplexes decreases acute toxicity and improves blood glycemic control in a mouse model of type II diabetes. International journal of pharmaceutics 577:119071

14. 叶松任凌丽陈曦赵冰杨洋翁翎曹鹏*叶娟*.王氏保赤丸对急性酒精损伤小鼠醒酒护肝/胃作用及机制研究[J].中国中药杂志202145(5):3900-3906.


—— 学术兼职 ——

个人简介:

叶娟,副研究员,硕士生导师。主持及参与国家/部省级等课题20余项;发表学术论文40余篇;作为主要完成人获南京中医药科学技术奖二等奖1项;参与发表论著1部;授权专利4项。现任江苏省药理学会中药药理专委会委员,江苏省合成生物标准化技术委员会委员。主要从事中药物质基础和作用机制研究,围绕代谢性疾病和中西医结合抗肿瘤方向,从中药复方或动物药中筛选天然有效的分子展开药理学和作用机制研究

近五年主持在研课题:

国家自然科学基金青年项目,82104508,王氏保赤丸通过B.pseudolongum PV8-2代谢产物拮抗ALD脂质沉积的作用机制研究,2022/01-2024/1230万元,主持,在研