师资队伍

金乔梅

专业代码:药学

专业名称:105500

学术/专业型:专业型

职务

  • 硕士生导师

—— 个人简介 ——

个人简介:

金乔梅,理学博士,副研究员,1988年出生2006年就读于中国药科大学基础药学理科基地班2015年于中国药科大学取得药物化学博士学位2015年至今就职于江苏省中医药研究院,主持及参与国家、省部级等项目3项,一作或通讯作者身份发表SCI论文20余篇,授权专利1项,参与获得省级科学技术进步奖2项。


近五年主持在研课题:

[1] 国家自然科学基金青年项目,新型大黄酸类坏死靶向MRI探针用于肿瘤热消融早期疗效评价及其基于后标记法的机制研究,219070932020.01-2022.12,25万元结题

[2] 南京中医药自然科学基金项目,新型Mps1抑制剂的发现、优化及抗三阴性乳腺癌活性研究,XZR20210382022.01-2024.128万元,在研


授权专利:

[1] 张健、卞丽、高萌、金乔梅、蒋翠花、张东建。磁共振成像造影剂,专利号:ZL201610838325.6.授权日期:2020.12.25


其他成果:

张健,倪以成,蒋翠花,张东建,金乔梅,高萌,姚楠,蒽醌类分子探针用于坏死组织诊断和治疗,江苏省中医药协会,江苏省中医药科学技术奖,二等奖,2019


联系方式:jqmxy@163.com


擅长: 运用计算机辅助药物设计、化学生物学、药物化学等多学科交叉技术,针对肿瘤等相关疾病开展创新药物研发工作。

—— 发表文章 ——

近五年发表文章:(按照参考文献格式列举)

[1] Shihe Hu Cuihua Jiang Meng Gao Dongjian Zhang Nan Yao Jian Zhang* Qiaomei Jin* Discovery of pyrazolo[34-b]pyridine derivatives as novel and potent Mps1 inhibitors for the treatment of cancer European Journal of Medicinal Chemistry 2023 253 115334.

[2] Shihe Hu* Yu Liu Jiye Ma Weijie Ding Hua Chen Haifang Jiang Hongxing Chen Song Wei Yonggao Liu Qiaomei Jin* Haoliang Yuan and Libo Yan* Discovery and Structural Optimization of Novel Quinolone Derivatives as Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors Journal of Medicinal Chemistry 2023 66 8858-8875.

[3] Cuihua Jiang# Jian Zhang# Shihe Hu Meng Gao Dongjian Zhang Nan Yao Qiaomei Jin* Target identification and occupancy measurement of necrosis avid agent rhein using biorthogonal chemistry-enabling probesRSC Advances 2022 12 16491-16495.

[4] Qiaomei Jin*# Cuihua Jiang# Meng Gao Dongjian Zhang Shihe Hu and Jian Zhang* Direct Cyclopropanation of Quinolinium Zwitterionic Thiolates via Dearomative Reactions J. Org. Chem. 2021 86 15640-15647.

[5] Dongjian Zhang# Qiaomei Jin# Yicheng Ni Jian Zhang* Discovery of necrosis avidity of rhein and its applications in necrosis imaging Journal of Drug Targeting 2020 9 904-912.

[6] Qiaomei Jin* Dongjian Zhang Jian Zhang* A [3 + 2] cycloaddition/C-arylation of isatin NN’-cyclic azomethine imine 13-dipole with arynes RSC Advances 2020 10 30620-30623.

[7] Qiaomei Jin Cuihua Jiang Meng Gao Dongjian Zhang Nan Yao Yuanbo Feng Tianze Wu Jian Zhang* Target exploration of rhein as a small-molecule necrosis avid agent by post-treatment click modification New Journal of Chemistry 2019 43 6121-6125.

[8] Qiaomei Jin* Dongjian Zhang Jian Zhang* Facile synthesis of 1245-tetrahydro-14-benzodiazepin-3-ones via cyclization of N-alkoxy α-halogenoacetamides with N-(2-chloromethyl)aryl amides Organic & Biomolecular Chemistry 2019 17 9708- 9711.


—— 学术兼职 ——